How This Works
Prostamax (KEDP) belongs to the class of short bioregulatory peptides studied by Khavinson and colleagues. These tetrapeptides are proposed to modulate gene expression through epigenetic mechanisms, interacting with chromatin structure and histone proteins[3][4]. In aged human lymphocytes, KEDP has been observed to cause pericentromeric chromatin decondensation, potentially reactivating suppressed genes[3]. Preclinical rat models of prostatitis showed that IM preparation of KEDP reduced inflammatory markers and helped prevent fibrotic changes in prostate tissue[1][2].
References
Modern Research in Inflammation (2013)
— Experimental study of Prostamax efficiency in chronic aseptic prostatitis research and complications
Modern Research in Inflammation (2014)
— Experimental study of tetrapeptide Lysyl-Glutamyl-Aspartyl-Proline in benign prostatic hyperplasia model
Bulletin of Experimental Biology and Medicine (2004)
— Effects of short peptides on lymphocyte chromatin in senile subjects (KEDP and chromatin decondensation)
Stem Cell Reviews and Reports (2020)
— Peptide regulation of cell differentiation: epigenetic mechanisms of short bioregulatory peptides
CDC
— Vaccine preparation: (IM) measurement guidelines for adults
View Source
CDC (Subcut Measurement PDF)
— Technique diagram and site guidance for measurements
CDC
— Vaccine preparation: During vaccination (aspiration guidance, aseptic technique)
NIBSC (MHRA)
— Peptide handling, dissolution, and storage best practices
NCBI Bookshelf
— Best practices for measurement (asepsis, preparation, and preparation)
CDC
— General best practices for immunization: handling reference and safety
Drug Measurement Review (PMC)
— Pharmacologic considerations of the route