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Research Reference

PNC-27 Research Reference

Complete research reference and reconstitution guide for PNC-27.

Research Use Only Reconstitution Math Storage Reference

Quick Reference

Vial Amount
30mg
CoreVials Standard Mix
Add 1mL BAC Water
Final Concentration
30mg/mL
Easy Reference
10 units = 3mg
Storage
Refrigerate after reconstitution

This page is for research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.

On this page

How This Works

PNC-27 is a chimeric peptide consisting of a segment derived from the p53 tumor suppressor protein (residues 12–26) fused to a membrane‑penetrating leader sequence[1]. Preclinical studies indicate that PNC-27 selectively binds to HDM‑2 expressed on the surface of cancer cells, inducing membrane destabilization and necrotic cell death while sparing normal cells[2][6]. Research in mouse tumor models has demonstrated inhibition of cancer cell growth via intraperitoneal preparation[4]. No human clinical studies have been conducted, and all measurement protocols remain theoretical extrapolations from preclinical work.

CoreVials Standard Mix

For a 30mg vial Add 1mL BAC Water
Final concentration 30mg/mL

After mixing (U-100 syringe reference)

  • 5 units=1.5mg
  • 10 units=3mg
  • 20 units=6mg

These are example measurement calculations only. They are not dosing, administration, medical, or veterinary guidance.

Other Mix Options
BAC Added Final Concentration 0.5mg Equals 1mg Equals
1mL CoreVials Standard Mix 30mg/mL 1.67 units 3.33 units
2mL 15mg/mL 3.33 units 6.67 units
3mL 10mg/mL 5 units 10 units

Supply Planning

Products commonly paired for research preparation:

  • PNC-27 Research Reference
  • BAC Water
  • Cryo labels
  • Storage case
Shop Peptides View BAC Water

References

Journal of Biomedical Science (2017)
— Review of research peptides; PNC-27 mechanism and cancer cell selectivity

Cancer Chemotherapy and Pharmacology (2010)
— PNC-27 induces tumor cell membrane lysis; preclinical mechanism study

FDA Drug Safety Communication (2015)
— Warning: PNC-27 is unapproved; safety not established

International Journal of Cancer (2006)
— PNC-28 (related peptide) blocks pancreatic cancer growth in vivo; mouse model study

Peptide Sciences
— Peptide storage guidelines: lyophilized and reconstituted stability

BMC Cancer (2008)
— PNC-27 selectively kills cancer cells via HDM-2 binding and membrane disruption

PubMed (2012)
— PNC-27 peptide induces necrosis via direct membrane lysis mechanism

CDC
— Vaccine preparation: route (angle/site guidance)

National Hemophilia Foundation (2021)
— measurement guidelines: needle length, angle, site preparation

NCBI Bookshelf
— Best practices for measurement (asepsis, preparation, and preparation)

Drug Measurement Review (PMC)
— Pharmacologic considerations of the route

Research Use Notice

This page is research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.

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High-purity peptides and lab essentials with batch-level COA transparency.

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Related Protocols

Research Use Only Products are for laboratory research only, not for human or animal consumption. Research Compliance