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Research Reference
PE-22-28 Research Reference
Complete research reference and reconstitution guide for PE-22-28.
Research Use Only
Reconstitution Math
Storage Reference
Quick Reference
Vial Amount
10mg
CoreVials Standard Mix
Add 1mL BAC Water
Final Concentration
10mg/mL
Easy Reference
10 units = 1mg
Storage
Refrigerate after reconstitution
This page is for research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.
PE-22-28 functions as a potent and selective antagonist of TREK-1 (KCNK2) two-pore domain potassium channels[2]. By blocking TREK-1, it depolarizes neurons and enhances excitability, leading to increased firing of serotonergic neurons and elevated monoamine neurotransmission[2]. This mechanism produces rapid antidepressant-like effects in preclinical models—within 4 days, PE-22-28 significantly increases hippocampal neurogenesis and synaptogenesis markers, changes typically requiring weeks with conventional antidepressants[4]. The peptide also activates CaMKII/CREB pathways that promote neuronal survival and plasticity[6]. PE-22-28 represents a shortened, optimized analog of spadin with superior potency (IC50 ~0.12 nM versus 40–60 nM for spadin) and longer duration of action (~23 hours versus ~7 hours)[4]. Notably, research also demonstrates neuroprotective effects in stroke models through biphasic measurement that leverages both TREK-1 activation at ultra-low doses and inhibition at standard doses[5].
CoreVials Standard Mix
For a 10mg vialAdd 1mL BAC Water
Final concentration10mg/mL
After mixing (U-100 syringe reference)
5 units=0.5mg
10 units=1mg
20 units=2mg
These are example measurement calculations only. They are not dosing, administration, medical, or veterinary guidance.
Other Mix Options
BAC Added
Final Concentration
0.5mg Equals
1mg Equals
1mL
CoreVials Standard Mix
10mg/mL
5 units
10 units
2mL
5mg/mL
10 units
20 units
3mL
3.33mg/mL
15 units
30 units
Supply Planning
Products commonly paired for research preparation:
PLoS Biology (2010)
— Mazella et al.: Spadin, a sortilin-derived peptide targeting TREK-1 channels; novel antidepressant mechanism
Neuropharmacology (2012)
— Moha Ou Maati et al.: Spadin as antidepressant; absence of TREK-1-related observations
Frontiers in Pharmacology (2017)
— Djillani et al.: Shortened spadin analogs (PE-22-28); superior TREK-1 inhibition, in vivo stability, antidepressant activity
Neuropharmacology (2019)
— Pietri et al.: Protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides
Pharmacological Research (2021)
— Daziano et al.: Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway
International Journal of Molecular Sciences (2022)
— Chang et al.: Potential of heterogeneous compounds as antidepressants; narrative review including TREK-1 modulators
CDC
— 4 Ways to Take Insulin; section on preparation area rotation and technique
CDC Pink Book
— General best practice guidelines: vaccine preparation; multi-dose vial 28-day sterility rule
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Research Use Notice
This page is research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.
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