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Research Reference

MOTS-C 40mg Research Reference

Complete research reference and reconstitution guide for MOTS-C 40mg.

Research Use Only Reconstitution Math Storage Reference

Quick Reference

Vial Amount
40mg
CoreVials Standard Mix
Add 0.8 mL (100 units) BAC Water
Final Concentration
50 mg/mL
Easy Reference
10 units = 5 mg
Storage
Refrigerate after reconstitution
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This page is for research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.

On this page

How This Works

MOTS-c functions as a metabolic “stress signal” that helps optimize energy usage during nutrient stress or exercise[2]. Its primary mechanism is AMPK activation through inhibition of the folate cycle, causing accumulation of AICAR (an AMP analog)[1][2]. Activated AMPK shifts cells into an energy-efficient mode – enhancing glucose uptake, fatty-acid oxidation, and mitochondrial respiration while downregulating fat storage and gluconeogenesis[2].

MOTS-c can also translocate to the cell nucleus under stress conditions and upregulate antioxidant and stress-response genes[2]. This retrograde signaling from mitochondria to nucleus increases expression of cytoprotective enzymes, helping cells cope with oxidative stress. Research indicates MOTS-c may also modulate mTOR and inflammatory pathways, contributing to lifespan and healthspan effects[10]. Its actions resemble those of exercise and metformin at a cellular level[2], making it of great interest for metabolic disorders, obesity, and aging research.

CoreVials Standard Mix

For a 40mg vial Add 0.8 mL (100 units) BAC Water
Final concentration 50 mg/mL

After mixing (U-100 syringe reference)

  • 5 units=2.5 mg
  • 10 units=5 mg
  • 20 units=10 mg

These are example measurement calculations only. They are not dosing, administration, medical, or veterinary guidance.

Other Mix Options
BAC Added Final Concentration Dose per 10 units
1 mL (100 units) CoreVials Standard Mix 10 mg/mL 1 mg
0.8 mL (100 units) 50 mg/mL 5 mg
2 mL (200 units) 20 mg/mL 2 mg
4 mL (400 units) 10 mg/mL 1 mg

Supply Planning

Products commonly paired for research preparation:

  • MOTS-c
  • BAC Water
  • Cryo labels
  • Storage case
Shop MOTS-c View BAC Water

References

Cell Metabolism (2015)
— The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance (Lee C, Zeng J, Drew BG, et al.)

Journal of Translational Medicine (2023)
— Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging (Wan W, Zhang L, Lin Y, et al.)

Journal of Molecular Medicine (2019)
— MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction (Lu H, Wei M, Zhai Y, et al.)

Nature Communications (2021)
— MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis (Reynolds JC, Lai RW, Woodhead JST, et al.)

Frontiers in Physiology (2023)
— Role of MOTS-c in the regulation of bone metabolism (Yi X, Hu G, Yang Y, et al.)

International Journal of Molecular Sciences (2022)
— MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases (Mohtashami Z, Singh MK, Salimiaghdam N, et al.)

Cognitive Vitality Reports (2021)
— MOTS-c (Cognitive Vitality Profile) – Alzheimer’s Drug Discovery Foundation (ADDF)

USADA Spirit of Sport (2023)
— What is the MOTS-c peptide? – U.S. Anti-Doping Agency education article

CDC Vaccine Preparation Guidelines
— route technique (angle, site selection, no aspiration)

Experimental & Molecular Medicine (2025)
— Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes (Kong BS, Lee H, L’Yi S, et al.)

MedlinePlus Medical Encyclopedia (2023)
— (SQ) measurements – Research sample instructions for proper technique

Drug Measurement Review (PMC)
— Literature review of factors influencing measurement pharmacology

Research Use Notice

This page is research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.

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Related Protocols

Research Use Only Products are for laboratory research only, not for human or animal consumption. Research Compliance