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Research Reference

LL-37 Research Reference

Complete research reference and reconstitution guide for LL-37.

Research Use Only Reconstitution Math Storage Reference

Quick Reference

Vial Amount
5mg
CoreVials Standard Mix
Add 1 mL (100 units) BAC Water
Final Concentration
5 mg/mL
Easy Reference
10 units = 500 mcg
Storage
Refrigerate after reconstitution

This page is for research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.

On this page

How This Works

LL-37 exerts both direct and indirect antimicrobial effects. Its amphipathic, cationic α-helical structure (net +6 charge) allows it to preferentially bind and disrupt negatively charged microbial membranes[2]. Beyond direct killing, LL-37 modulates host immunity: in murine sepsis models, it induced neutrophils to release microvesicles rich in antimicrobial proteins, lowering bacterial burden and improving survival[3]. LL-37 can also bind bacterial lipopolysaccharide (LPS) and block its interaction with CD14/TLR4, reducing endotoxin-triggered TNF release and neutrophil apoptosis[2]. These combined mechanisms help explain its potential in infection control and tissue-repair contexts.

CoreVials Standard Mix

For a 5mg vial Add 1 mL (100 units) BAC Water
Final concentration 5 mg/mL

After mixing (U-100 syringe reference)

  • 5 units=250 mcg
  • 10 units=500 mcg
  • 20 units=1000 mcg

These are example measurement calculations only. They are not dosing, administration, medical, or veterinary guidance.

Other Mix Options
BAC Added Final Concentration Dose per 10 units
1 mL (100 units) CoreVials Standard Mix 5 mg/mL 500 mcg
2 mL (200 units) 2.5 mg/mL 250 mcg
2.5 mL (250 units) 2 mg/mL 100 mcg

Supply Planning

Products commonly paired for research preparation:

  • LL-37 Research Reference
  • BAC Water
  • Cryo labels
  • Storage case
Shop Peptides View BAC Water

References

DiVA Portal / Wound Repair and Regeneration
— Evaluation of LL-37 in healing of hard-to-heal venous leg ulcers: multicentric RCT

View Source

Journal of Immunology (PMC)
— Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease

Innate Immunity (PMC)
— Antimicrobial peptide LL-37 ameliorates a murine sepsis model via microvesicle release from neutrophils

Wound Repair and Regeneration (PMC)
— Evaluation of LL-37 in healing of hard-to-heal venous leg ulcers: a multicentric prospective RCT

Archives of Dermatological Research (PMC)
— Efficacy of LL-37 cream in enhancing healing of diabetic foot ulcer: a randomized double-blind controlled trial

Bachem Knowledge Center
— Handling and storage guidelines for peptides

CDC One & Only Campaign
— One needle, one syringe, only one time (measurement safety)

Johns Hopkins Arthritis Center
— How to give a measurement (site selection, rotation)

PubMed / Journal of Steroid Biochemistry
— Vitamin D and the antimicrobial peptide cathelicidin (LL-37)

MedlinePlus (NIH)
— (SQ) measurements: research sample instructions

CDC
— Vaccine preparation: measurement (angle/site; no aspiration)

NCBI Bookshelf
— Best practices for measurement (asepsis, preparation, and preparation)

Clinical Pharmacology & Therapeutics (PMC)
— drug measurement review: pharmacologic considerations

Research Use Notice

This page is research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.

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High-purity peptides and lab essentials with batch-level COA transparency.

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Related Protocols

Research Use Only Products are for laboratory research only, not for human or animal consumption. Research Compliance