Standard Protocol (2 mL = 2,500 IU/mL)
| Week/Phase | Dose per Measurement (IU) | Units (per measurement) (mL) |
|---|---|---|
| Weeks 1–12 | 500 IU | 20 units (0.20 mL) |
Frequency: Measure 3 times weekly (e.g., Monday/Wednesday/Friday). This yields a total weekly dose of 1,500 IU. This schedule maintains intratesticular testosterone during exogenous testosterone research and supports fertility preservation[3][4].
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water with a sterile syringe.
- Measure slowly down the vial wall; avoid foaming or vigorous shaking.
- Gently swirl or roll until the powder fully dissolves (clear solution).
- Label vial with reconstitution date and concentration (2,500 IU/mL); refrigerate immediately at 2–8 °C (35.6–46.4 °F).
Measurement Calculations:
- 250 IU = 10 units (0.10 mL)
- 500 IU = 20 units (0.20 mL)
- 1,000 IU = 40 units (0.40 mL)
High‑Dose Protocol (for Post‑Cycle Recovery or Severe Suppression)
| Week/Phase | Dose per Measurement (IU) | Units (per measurement) (mL) |
|---|---|---|
| Weeks 1–4 | 1,500 IU | 60 units (0.60 mL) |
| Weeks 5–8 | 2,000 IU | 80 units (0.80 mL) |
| Weeks 9–12 | 1,000 IU | 40 units (0.40 mL) |
Frequency: Measure 3 times weekly. High‑dose protocols (1,500–2,500 IU per measurement) are used to reactivate testosterone production after prolonged anabolic steroid use or severe hypogonadotropic hypogonadism[5][6]. After initial recovery, doses are typically reduced to maintenance levels (500–1,000 IU 3×/week).
Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.
How This Works
HCG is a glycoprotein hormone structurally similar to luteinizing hormone (LH). It binds to the same LH receptors in testicular Leydig cells, stimulating endogenous testosterone production[1]. Unlike endogenous LH (which has a 30‑minute half‑life), HCG’s extended 36‑hour half‑life provides sustained gonadal stimulation[2]. This makes it effective for maintaining testicular function during exogenous testosterone research, where natural LH production is suppressed. Studies show that low‑dose HCG (250–500 IU every other day) maintains intratesticular testosterone at near‑baseline levels in men receiving testosterone research[4]. Higher doses (1,500–5,000 IU multiple times weekly) are used to restore spermatogenesis and endogenous testosterone production in cases of hypogonadotropic hypogonadism or post‑anabolic steroid recovery[5][6].