Standard / Maintenance Approach (2 mL = 1 mg/mL)
Route: measurement. Frequency: 2–3 times per week on non‑consecutive days (e.g., Mon/Wed/Fri or Tue/Thu/Sat).
| Week/Phase | Dose per Measurement (mcg) | Units (mL) |
|---|---|---|
| Weeks 1–2 (Initiation) | 50 mcg | 5 units (0.05 mL) |
| Weeks 3–4 (Titration) | 100 mcg | 10 units (0.10 mL) |
| Weeks 5–8 (Maintenance) | 100–150 mcg | 10–15 units (0.10–0.15 mL) |
For ≤10‑unit (≤0.10 mL) administrations, consider 30‑ or 50‑unit insulin syringes for improved readability.
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water with a sterile syringe.
- Measure slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake).
- Label concentration (1 mg/mL) and date; refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Advanced / Post‑Cycle Support Approach
Route: measurement. Frequency: Daily or every other day for short cycles (limit to ≤14 consecutive days to avoid pituitary desensitization).
| Week/Phase | Dose per Measurement (mcg) | Units (mL) |
|---|---|---|
| Days 1–7 (Burst) | 200 mcg | 20 units (0.20 mL) |
| Days 8–14 (Taper) | 100 mcg | 10 units (0.10 mL) |
| Week 3+ (Optional Maintenance) | 100 mcg 2–3×/wk | 10 units (0.10 mL) |
Important: Limit consecutive example calculation to ≤14 days. Extended continuous preparation may lead to GnRH receptor desensitization and reduced LH/FSH response[4].
Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.
How This Works
Gonadorelin is a synthetic decapeptide identical to endogenous gonadotropin‑releasing hormone (GnRH) secreted by the hypothalamus[1]. When prepared in short, pulsatile fashion, it binds to GnRH receptors on pituitary gonadotrophs, triggering the release of luteinizing hormone (LH) and follicle‑stimulating hormone (FSH)[2][3]. LH stimulates Leydig cells to produce testosterone in men and triggers ovulation in women, while FSH supports spermatogenesis and ovarian follicle development[5]. Unlike continuous GnRH agonist preparation, which desensitizes receptors and suppresses gonadotropins, brief periodic measurement preserves the natural pulsatile signaling pattern[4][6].