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Research Reference

FOXO4-DRI Research Reference

Complete research reference and reconstitution guide for FOXO4-DRI.

Research Use Only Reconstitution Math Storage Reference

Quick Reference

Vial Amount
10mg
CoreVials Standard Mix
Add 1 mL (100 units) BAC Water
Final Concentration
10 mg/mL
Easy Reference
10 units = 1 mg
Storage
Refrigerate after reconstitution

This page is for research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.

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How This Works

FOXO4-DRI is a synthetic peptide that selectively targets senescent cells by blocking the FOXO4–p53 protein interaction[1][2]. In normal cells, FOXO4 binds to p53 and sequesters it in the nucleus. In senescent cells, disrupting this interaction causes p53 to translocate to the mitochondria, triggering apoptotic cell death specifically in aged, dysfunctional cells while sparing healthy ones[1]. Animal studies have demonstrated that FOXO4-DRI can reduce senescent cell burden, improve tissue function, and mitigate age-related pathologies[3][4][5]. The peptide’s D-retro-inverso configuration enhances its stability and resistance to proteolytic degradation[2].

CoreVials Standard Mix

For a 10mg vial Add 1 mL (100 units) BAC Water
Final concentration 10 mg/mL

After mixing (U-100 syringe reference)

  • 5 units=0.5 mg
  • 10 units=1 mg
  • 20 units=2 mg

These are example measurement calculations only. They are not dosing, administration, medical, or veterinary guidance.

Other Mix Options
BAC Added Final Concentration Dose per 10 units
1 mL (100 units) CoreVials Standard Mix 10 mg/mL 1 mg
2 mL (200 units) 5 mg/mL 0.50 mg

Supply Planning

Products commonly paired for research preparation:

  • FOXO4-DRI Research Reference
  • BAC Water
  • Cryo labels
  • Storage case
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References

Nature Communications Biology
— FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

Nature Cell
— Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging (original FOXO4-DRI discovery)

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Aging (Albany NY)
— FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice

Journal of Cellular and Molecular Medicine
— FOXO4 peptide targets myofibroblast ameliorates bleomycin-induced pulmonary fibrosis in mice

Cell
— Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice (senolytic mechanism context)

Aging (Albany NY) — Methods & Protocols
— FOXO4-DRI safety note: no human clinical measurement data exist yet

PubMed
— A liquid chromatography high-resolution mass spectrometry in vitro assay to assess metabolism at the preparation area of prepared research peptides

Bachem
— Care and Handling of Peptides (storage, reconstitution, stability guidance)

MedlinePlus
— (SQ) measurements: technique, site selection, and safety

American Diabetes Association
— Insulin preparation area rotation and lipohypertrophy prevention

CDC
— Vaccine preparation: route (angle, site; no aspiration)

CDC ( Measurement PDF)
— Technique diagram and site guidance for measurements

NCBI Bookshelf
— Best practices for measurement (asepsis, preparation, and preparation)

PMC
— Drug Measurement Review: pharmacologic considerations of the route

Research Use Notice

This page is research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.

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High-purity peptides and lab essentials with batch-level COA transparency.

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Related Protocols

Research Use Only Products are for laboratory research only, not for human or animal consumption. Research Compliance