Standard Approach (3 mL = 6.67 mg/mL)
| Week | Example amount (mcg) | Units (per measurement) (mL) |
|---|---|---|
| Weeks 1–2 | 1000 mcg | 15 units (0.15 mL) |
| Weeks 3–4 | 2000 mcg | 30 units (0.30 mL) |
Frequency: Measure once daily, preferably in the morning[5]. This schedule uses the largest practical dilution (3.0 mL) to keep per-measurement units ≥15 for accurate measurement. For doses under ~10 units ( <700 mcg), consider using 50-unit or 30-unit insulin syringes for improved readability.
Reconstitution Steps
- Draw 3.0 mL bacteriostatic water with a sterile syringe.
- Measure slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake).
- Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.
How This Works
Cortagen (Ala-Glu-Asp-Pro) is a synthetic tetrapeptide derived from amino acid analysis of the natural brain cortex preparation Cortexin[3]. It acts as a gene expression modulator and epigenetic regulator, influencing the synthesis of proteins involved in neuronal growth, differentiation, and stress resistance[6][7]. Preclinical studies demonstrate that Cortagen can upregulate neurotrophic factors, reduce oxidative stress markers, and accelerate peripheral nerve regeneration—increasing nerve fiber growth rate and conduction velocity by 27–40% in injury models[1]. In chronic cerebral ischemia models, Cortagen improved behavioral recovery and protected against oxidative damage[2].