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Research Reference

Ara-290 Research Reference

Complete research reference and reconstitution guide for Ara-290.

Research Use Only Reconstitution Math Storage Reference

Quick Reference

Vial Amount
10mg
CoreVials Standard Mix
Add 1 mL (100 units) BAC Water
Final Concentration
10 mg/mL
Easy Reference
10 units = 1 mg
Storage
Refrigerate after reconstitution

This page is for research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.

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How This Works

Ara-290 (cibinetide) binds to the innate repair receptor (IRR), a heterodimer of EPOR and CD131 (βc subunit), which is distinct from the classical erythropoietin receptor[1][2]. This selective binding triggers anti-apoptotic and anti-inflammatory signaling cascades that protect tissues and promote repair without stimulating erythropoiesis[9]. Preclinical research demonstrates that Ara-290 can reprogram a pro-inflammatory, tissue-damaging environment into one favoring healing and regeneration[10]. Additionally, analgesic effects have been observed through immunomodulation and direct inhibition of TRPV1 ion channels activated by capsaicin[11].

CoreVials Standard Mix

For a 10mg vial Add 1 mL (100 units) BAC Water
Final concentration 10 mg/mL

After mixing (U-100 syringe reference)

  • 5 units=0.5 mg
  • 10 units=1 mg
  • 20 units=2 mg

These are example measurement calculations only. They are not dosing, administration, medical, or veterinary guidance.

Other Mix Options
BAC Added Final Concentration Dose per 10 units
1 mL (100 units) CoreVials Standard Mix 10 mg/mL 1 mg
2 mL (200 units) 5 mg/mL 0.50 mg

Supply Planning

Products commonly paired for research preparation:

  • Ara-290 Research Reference
  • BAC Water
  • Cryo labels
  • Storage case
Shop Peptides View BAC Water

References

IUPHAR/BPS Guide to Pharmacology
— Cibinetide (ARA-290) ligand profile: structure, receptor binding, and pharmacology

Molecular Medicine (2008)
— Brines & Cerami: Discovery and development of the innate repair receptor and its non-erythropoietic ligands

View Source

Molecular Medicine (2014)
— Brines M. et al.: ARA 290 improves metabolic control and neuropathic symptoms in research samples with type 2 diabetes

Molecular Medicine (2013)
— Dahan A. et al.: ARA 290 improves symptoms in sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density

ClinicalTrials.gov (NCT02039687)
— Phase 2 study of ARA 290 on corneal nerve fiber density in sarcoidosis (1 mg vs 4 mg vs 8 mg daily SC for 28 days)

NCBI Bookshelf
— Stability and storage considerations for lyophilized peptide formulations

USP General Chapters
— Pharmaceutical compounding with bacteriostatic water: stability and beyond-use dating

Cleveland Clinic
— measurements: where and how to prepare at home

Pain Reports (2017)
— Davis T. et al.: Targeting the innate repair receptor to treat neuropathy (review of ARA-290 mechanisms)

Investigative Ophthalmology & Visual Science (2016)
— Cibinetide improves corneal nerve fiber abundance in research samples with sarcoidosis-associated small fiber neuropathy

Peptides Journal (2016)
— Zhang W. et al.: ARA 290 relieves pathophysiological pain by targeting TRPV1 channel

Johns Hopkins Arthritis Center
— How to give a measurement: research sample guide

CDC
— Vaccine preparation: route (angle, site, and technique guidance)

PMC Drug Delivery Review
— Pharmacologic considerations of the measurement route

Research Use Notice

This page is research-use-only educational reference and measurement math. It is not medical, veterinary, dosing, administration, or treatment guidance. Products are not for human or animal consumption.

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High-purity peptides and lab essentials with batch-level COA transparency.

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Related Protocols

Research Use Only Products are for laboratory research only, not for human or animal consumption. Research Compliance