How This Works
KLOW combines four peptides with complementary mechanisms of action:
- TB-500 (Thymosin Beta-4): Promotes angiogenesis, cell migration, and tissue repair by regulating actin, a key protein in cell structure[1]. Preclinical studies demonstrate accelerated wound healing, reduced inflammation, and tissue regeneration[2].
- BPC-157: A gastric pentadecapeptide that supports tendon, ligament, and muscle healing through enhanced angiogenesis and growth factor modulation[3]. Animal studies show favorable tissue repair outcomes[4].
- KPV: A C-terminal tripeptide fragment of α-MSH with potent anti-inflammatory properties. It inhibits NF-κB signaling and reduces pro-inflammatory cytokines without melanotropic effects[5][6].
- GHK-Cu: A naturally occurring copper peptide that stimulates collagen and elastin synthesis, promotes wound healing, and modulates gene expression related to tissue remodeling[7][8].
References
PubMed
— Thymosin beta 4 accelerates wound healing (Philp et al., 1999)
PubMed
— Thymosin β4 promotes dermal healing in preclinical models and clinical trials
PMC
— Emerging use of BPC-157 in orthopaedic sports medicine: systematic review
PMC
— Pharmacokinetics, distribution, metabolism, and excretion of BPC-157 in rats and dogs
PMC
— PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
PMC
— Orally targeted delivery of tripeptide KPV via HA-functionalized nanoparticles alleviates ulcerative colitis
PMC
— Regenerative and protective actions of the GHK-Cu peptide in light of new gene data
PMC
— GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration
Sigma-Aldrich
— Handling and storage guidelines for peptides and proteins
CDC
— Vaccine preparation: handling reference guidelines
CDC
— Vaccine preparation best practices (aspiration not recommended for SC measurements)
NCBI Bookshelf
— Chapter 18: Preparation of parenteral medications (handling reference)
PubMed
— Thymosin β4: a multi-functional regenerative peptide (basic properties and clinical applications)
PMC
— The potential of GHK as an anti-aging peptide